![]() ![]() Mainly, these protective effects were attributed to its anti-oxidant, anti-apoptotic and anti-inflammatory properties ( Santos-Gallego et al., 2016 Ahmed et al., 2017). It has been demonstrated to protect the heart against myocardial injury in various animal models ( Kennedy et al., 2009 Santos-Gallego et al., 2016 Ahmed, 2017 Ahmed et al., 2017). FTY720 preserves high-energy phosphates attenuates myocardial inflammation and oxidative stress, and improves cardiac function.įingolimod (FTY720), an immunomodulator drug targeting the sphingosine-1-phosphate (S1P) receptor with anti-inflammatory properties, is a widely recommended drug for relapsing-remitting multiple sclerosis ( Pelletier and Hafler, 2012 Ayzenberg et al., 2016). This resulted in improved recovery of left ventricular systolic and diastolic functions.Ĭonclusion: The cardioprotective mechanism in CPA is associated with activation of prosurvival cell signaling pathways that prevents myocardial damage. Moreover, significant preservation of high-energy phosphates were observed in the FTY720-treated group. Results: FTY720 treatment activated the Akt/Erk1/2 signaling pathways, reduced the level of inflammatory mediators, activated antiapoptotic proteins, and inhibited proapoptotic proteins, leading to reduced nitro-oxidative stress and cardiomyocyte apoptosis. Hemodynamic parameters, inflammatory mediators, nitro-oxidative stress, neutrophil infiltration, immunoblotting analysis, and immunohistochemical staining were analyzed and compared between groups. Support weaning was done, and blood and myocardial tissues were collected for analysis. After 15 min of treatment, rats underwent CPA for 30 min followed by initiation of extracorporeal life support for 2 h. Methods: 30 Sprague–Dawley rats (300–350 g) were randomized into two groups: Group-A, treated with FTY720 1 mg/kg via intravenous cannulation, and Group-B, as control. In this preclinical model, we have investigated the effects of FTY720 on myocardium during reperfusion in an experimental model of cardioplegic arrest (CPA) and cardiopulmonary bypass. Furthermore, FTY720 might be a key pharmacological target for preconditioning. Objective: FTY720, an immunomodulator derived from sphingosine-1-phosphate, has recently demonstrated its immunomodulatory, anti-inflammatory, anti-oxidant, anti-apoptotic and anti-inflammatory properties. ![]()
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